4136-97-4
- Product Name：Methyl-4-Aminosalicylate
- Molecular Formula：C8H9NO3
- Purity：99%
- Molecular Weight：167.164
Product Details;
CasNo： 4136-97-4
Molecular Formula： C8H9NO3
Buy Good Quality Methyl-4-Aminosalicylate 4136-97-4 with a minimum purity of 99%
- Molecular Formula:C8H9NO3
- Molecular Weight:167.164
- Vapor Pressure:9.21E-05mmHg at 25°C
- Melting Point:120-123oC
- Refractive Index:1.605
- Boiling Point:329.5 °C at 760 mmHg
- PKA:9.81±0.10(Predicted)
- Flash Point:153.1 °C
- PSA：72.55000
- Density:1.305 g/cm3
- LogP:1.34220
METHYL 4-AMINOSALICYLATE(Cas 4136-97-4) Usage
InChI:InChI=1/C8H9NO3/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4,10H,9H2,1H3
4136-97-4 Relevant articles
FePd alloy nanoparticles assembled on reduced graphene oxide as a catalyst for selective transfer hydrogenation of nitroarenes to anilines using ammonia borane as a hydrogen source
Metin, ?nder,Mendoza-Garcia, Adriana,Dalmizrak, Di?dem,Gültekin, Mehmet Serdar,Sun, Shouheng
, p. 6137 - 6143 (2016)
Addressed herein is a facile protocol fo...
Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design
Zagni, Chiara,Pistarà, Venerando,Oliveira, Luciana A.,Castilho, Rogerio M.,Romeo, Giovanni,Chiacchio, Ugo,Rescifina, Antonio
, p. 188 - 196 (2017)
Histone deacetylase inhibitors (HDACis) ...
Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside
Li, Feifei,Wu, Guoli,Zheng, Huixia,Wang, Li,Zhao, Zhengbao
, p. 486 - 494 (2016)
A glycoside prodrug of 4-aminosalicylic ...
Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS)
Aldrich, Courtney C.,Baughn, Anthony D.,Boshoff, Helena I. M.,Dartois, Veronique,Hegde, Pooja V.,Howe, Michael D.,Jia, Ziyi,Pan, Yan,Remache, Brianna,Sharma, Sachin,Zimmerman, Matthew D.
, (2022/02/25)
Tuberculosis (TB) is one of the world's ...
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens
Durcik, Martina,Nyerges, ákos,Skok, ?iga,Skledar, Darja Gramec,Trontelj, Jurij,Zidar, Nace,Ila?, Janez,Zega, Anamarija,Cruz, Cristina D.,Tammela, P?ivi,Welin, Martin,Kimbung, Yengo R.,Focht, Dorota,Benek, Ond?ej,Révész, Tamás,Draskovits, Gábor,Szili, Petra éva,Daruka, Lejla,Pál, Csaba,Kikelj, Danijel,Ma?i?, Lucija Peterlin,Toma?i?, Tihomir
, (2021/02/01)
The rise in multidrug-resistant bacteria...
Synthesis and biological evaluation of salicylic acid analogues of celecoxib as a new class of selective cyclooxygenase-1 inhibitor
Yoon, Sung-Hwa,Cho, Duk-Yeon,Choi, Seoung-Ryoung,Lee, Joo-Young,Choi, Dong-Kug,Kim, Eunha,Park, Ju-Young
, p. 1230 - 1238 (2021/09/06)
A series of salicylic acid analogues of ...
Fluoroquinolone derivative of p-aminosalicylic acid as well as intermediate, preparation method and application of fluoroquinolone derivative
-
Paragraph 0051-0054, (2021/01/24)
The invention discloses a fluoroquinolon...
4136-97-4 Process route
-
-
67-56-1
methanol
-
-
65-49-6
4-Aminosalicylic acid
-
-
4136-97-4
methyl 4-aminosalicylate
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
at 20 ℃;
for 10h;
Reflux;
|
95% |
|
With
sulfuric acid;
at 0 - 20 ℃;
for 6h;
Reflux;
|
93% |
|
With
sulfuric acid;
at 0 ℃;
for 6h;
Reflux;
|
93% |
|
With
sulfuric acid;
at 80 ℃;
for 22h;
Inert atmosphere;
|
92% |
|
With
sulfuric acid;
at 0 - 80 ℃;
for 6h;
|
92.1% |
|
With
sulfuric acid;
Reflux;
|
91.7% |
|
With
sulfuric acid;
In
water;
for 16h;
Reflux;
|
90% |
|
With
sulfuric acid;
at 0 - 80 ℃;
for 6h;
|
90% |
|
With
sulfuric acid;
at 0 - 80 ℃;
for 6h;
|
90% |
|
With
sulfuric acid;
for 20h;
Heating;
|
88% |
|
With
boron trifluoride diethyl etherate;
at 1 - 55 ℃;
for 24.0833h;
|
88% |
|
With
sulfuric acid;
at 65 ℃;
for 24h;
|
88.6% |
|
With
sulfuric acid;
for 14h;
Heating;
|
87% |
|
With
sulfuric acid;
for 12h;
Heating;
|
87% |
|
With
sulfuric acid;
at 0 ℃;
for 12h;
Reflux;
|
87% |
|
methanol; 4-Aminosalicylic acid;
With
sulfuric acid;
for 48h;
Cooling with ice;
Reflux;
With
sodium hydrogencarbonate;
at 20 ℃;
|
86% |
|
With
sulfuric acid;
at 22 ℃;
|
84% |
|
With
sulfuric acid;
for 24h;
Reflux;
|
81.4% |
|
With
sulfuric acid;
for 24h;
Reflux;
|
81.4% |
|
methanol;
With
sulfuric acid;
at 20 ℃;
for 1h;
Cooling with ice;
4-Aminosalicylic acid;
at 60 - 70 ℃;
for 6h;
|
77% |
|
With
sulfuric acid;
for 5h;
Reflux;
|
76.1% |
|
acetyl chloride;
for 20h;
Heating;
|
75% |
|
With
sulfuric acid;
for 4h;
Reflux;
|
65.7% |
|
With
sulfuric acid;
at 20 ℃;
Cooling with ice;
Reflux;
|
65% |
|
With
sulfuric acid;
Cooling with ice;
Reflux;
|
65% |
|
With
sulfuric acid;
Reflux;
Cooling with ice;
|
65% |
|
With
sulfuric acid;
Reflux;
|
58% |
|
With
sulfuric acid;
for 24h;
Reflux;
|
54% |
|
With
sulfuric acid;
for 36h;
Heating;
|
53% |
|
methanol; 4-Aminosalicylic acid;
With
thionyl chloride;
at 0 - 70 ℃;
for 15h;
With
thionyl chloride;
In
tetrahydrofuran;
at 82 ℃;
for 15h;
|
26% |
|
With
diethyl ether; boron trifluoride;
|
|
|
With
sulfuric acid;
|
|
|
With
sulfuric acid;
at 20 ℃;
for 2h;
|
|
|
With
sulfuric acid;
Reflux;
|
|
|
With
sulfuric acid;
at 80 ℃;
|
|
|
With
sulfuric acid;
for 4h;
Reflux;
|
|
|
With
toluene-4-sulfonic acid;
at 60 - 65 ℃;
for 3h;
|
|
|
methanol;
With
sulfuric acid;
at 20 ℃;
for 2h;
Reflux;
Inert atmosphere;
4-Aminosalicylic acid;
for 20h;
Reflux;
Inert atmosphere;
|
-
-
7664-93-9
sulfuric acid
-
-
65-49-6
4-Aminosalicylic acid
-
-
4136-97-4
methyl 4-aminosalicylate
| Conditions | Yield |
|---|---|
|
In
methanol;
|
62% |
4136-97-4 Upstream products
-
186581-53-3
diazomethane
-
65-49-6
4-Aminosalicylic acid
-
13684-28-1
2-hydroxy-4-nitro-benzoic acid methyl ester
-
67-56-1
methanol
4136-97-4 Downstream products
-
6950-58-9
2-hydroxy-4-(2-hydroxy-ethylamino)-benzoic acid methyl ester
-
114554-96-0
N-(3-hydroxy-4-methoxycarbonyl-phenyl)-maleamic acid
-
105106-30-7
N-(3-hydroxy-4-methoxycarbonyl-phenyl)-succinamic acid
-
28744-43-6
4-amino-2-hydroxy-benzoic acid-(2-hydroxy-ethylamide)
Relevant Products
-
Atosiban AcetateCAS：90779-69-4
-
Sodium 4-aminosalicylateCAS：133-10-8
-
Methyl 4-acetamido-2-methoxybenzoateCAS：4093-29-2
